Affiliation:
1. College of Chemistry Pingyuan Laboratory State Key Laboratory of Antiviral Drugs Zhengzhou University Zhengzhou 450001 People's Republic of China
Abstract
AbstractA transition‐metal‐free dearomative aza‐spirocyclization reaction of 2,3‐disubstituted indoles is established by using molecular iodine under basic conditions. The required substrates were prepared via sequential Fisher indole synthesis and sulfonylation. This dearomatization reaction is amenable to gram‐scale synthesis, and provides access to various spiroindolenine derivatives from indole sulfonamide precursors.
Funder
National Natural Science Foundation of China