Affiliation:
1. School of Pharmaceutical Science Hengyang Medical School University of South China Hengyang Hunan 421001 People's Republic of China
2. MOE Key Lab of Rare Pediatric Diseases University of South China Hengyang Hunan 421001 People's Republic of China
Abstract
AbstractA photoredox‐catalyzed three‐component sulfonaminoformyloxylation reaction between alkenes, N‐aminopyridinium salts and DMF has been developed, which avoids the usage of erosive formic acid as the formyloxylation reagent. Besides DMF, alkyl and aryl carboxylic acids proved to be feasible nucleophiles to afford various β‐amino esters. The robustness of this method was further demonstrated by its applicability in the late‐stage modification of biological molecules. Control experiments suggested that a sulfonamidyl radical was involved in this reaction.
Funder
National Natural Science Foundation of China
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
Cited by
1 articles.
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