Affiliation:
1. Cardiff Catalysis Institute School of Chemistry Cardiff University Main Building, Park Place Cardiff CF10 3AT UK
2. School of Pharmacy University College London 29-39 Brunswick Square, Bloomsbury London WC1 N 1AX UK
Abstract
AbstractA mechanochemical nickel‐catalyzed intramolecular difunctionalization reaction of alkene tethered aryl halides with alkyl halides is herein described. This method allows for synthesis of 3,3‐disubstituted heterocycles, namely oxindoles, with shorter reaction times than solution‐phase counterparts. Additionally, this process is solvent minimized, with DMA used in liquid‐assisted grinding (LAG) quantities and circumvents the need for chemical activation of the terminal reductant (manganese) through mechanical grinding. The process can be scaled up to yield over a gram of product and modest enantioinduction is possible by utilizing a chiral PyrOx ligand.magnified image
Funder
School of Chemistry, Cardiff University
Engineering and Physical Sciences Research Council
Cited by
2 articles.
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