Affiliation:
1. Department of Chemistry and Institution for Functional Materials Pusan National University 46241 Busan Republic of Korea
Abstract
AbstractSelective reduction of nitro‐containing arenes and heteroarenes was achieved in 5 minutes at room temperature utilizing inexpensive NaBH4 as a hydrogen source and a newly developed Ni@N−C catalyst, obtained via a simple carbon coating process without the need for an external carbon source. A wide variety of nitro derivatives, including pharmaceutical molecules, was successfully reduced to the corresponding amines in yields ranging from 45% to 99% using the Ni@N−C catalyst under general batch conditions. The reactivity and selectivity of the nitro reduction were further enhanced by a continuous flow reaction system, especially when a newly designed Y‐type column was used, and the Osimertinib intermediate was produced on gram scale after 24 hours without any nickel metal contamination or silica gel chromatography purification.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献