Copper‐Catalyzed Radical Silylarylation of Activated Alkenes: Preparation of <i>β</i>‐Silyl Amide‐Pharmaceutical Hybrids-Reference-Cited by-同舟云学术

Copper‐Catalyzed Radical Silylarylation of Activated Alkenes: Preparation of β‐Silyl Amide‐Pharmaceutical Hybrids

Published:2024-02-15 Issue:6 Volume:366 Page:1325-1330
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Chen Fei¹^ORCID,Liu Shi‐Yu¹,Li Xiao¹,Jia Jia‐Lu¹,Li Yi¹,Lu Xiao‐Lan¹,Jia Lin¹,Zheng Yang¹,Yan Zhongfei¹,Li Gang¹^ORCID,Lv Yunhe¹^ORCID,Rong Haojie²

Affiliation:

1. Henan Province Key Laboratory of New Optoelectronic Functional Materials Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs College of Chemistry and Chemical Engineering Anyang Normal University Anyang 455000 People's Republic of China

2. State Key Laboratory of Fluorine & Nitrogen Chemicals Modern Chemistry Research Institute of Xi'an Xi'an 710065 People's Republic of China

Abstract

AbstractCopper‐catalyzed silylarylation of N‐(arylsulfonyl)acrylamides via a tandem silyl radical addition/1,4‐aryl migration/desulfonylation sequence has been developed. This method employs silanes as the precursor of silyl radical and di‐tert‐butyl peroxide (DTBP) as the initiator. By using this cascade procedure, a series of β‐silyl amide‐pharmaceutical hybrids which contain an α‐all‐carbon quaternary stereocenter were facilely synthesized.

Funder

National Natural Science Foundation of China

Anyang Normal University

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202301434

Reference108 articles.

2. Uses of Silicon-Containing Compounds in the Synthesis of Natural Products

3. Exploitation of silicon medicinal chemistry in drug discovery

5. Synthesis and Evaluation of Silanediols as Highly Selective Uncompetitive Inhibitors of Human Neutrophil Elastase

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