Affiliation:
1. National Institute of Technology Anan College 265 Aoki Minobayashi Anan Tokushima 774-0017 Japan
2. Department of Materials & Life Chemistry Kanagawa University 3-27-1 Rokkakubashi Kanagawa-ku Yokohama 221-8686 Japan
Abstract
AbstractReactivity of nitriles in a CoCl2−6H2O/dppe/Zn‐catalyzed diyne‐nitrile cycloaddition was explored through the competitive reactions of a diyne with two different nitriles, and it was found that cyanamides are good substrates, and the reaction yielded 2‐aminopyridines. Notably, N‐unsubstituted cyanamide (H2N−CN) could be used for the reaction with 1,6‐diynes to afford the corresponding N‐unsubstituted 2‐aminopyridines, which cannot be prepared via other catalytic reactions and are versatile intermediates for further transformations such as the synthesis of 2‐substituted pyridines and 6,7‐annulated imidazo[1,2‐a]pyridines.
Funder
Ministry of Education, Culture, Sports, Science and Technology
Cited by
1 articles.
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