Affiliation:
1. School of Chemistry and Chemical Engineering Shandong University Jinan Shandong 250100 People's Republic of China
Abstract
AbstractA nickel‐catalyzed reductive cross coupling reaction of carboxylic acids with disulfides is described. The readily available and inexpensive carboxylic acid is activated in situ by the formation of a mixed anhydride. The transformation occurs at room temperature with wide functional group tolerance to efficiently generate structurally diverse thioesters. Moreover, the reaction tolerated a broad substrate scope, including sterically hindered of disulfides. Ultimately, this powerful method could be applied to the late‐stage functionalization for the construction of diverse thioesters, affording a convenient and practical tactic to construct carbon‐sulfur bonds.
Funder
National Natural Science Foundation of China
Shandong University