FeCl3‐Catalyzed C(sp3)−H Heteroarylation Enabled by Photoinduced Ligand‐to‐Metal Charge Transfer

Abstract

AbstractHerein, we report a strategy for pyrimidination of inert alkanes via synergistic visible light‐driven redox reaction and FeCl3 catalysis. This transformation involves C−H activation by a chlorine radical generated during the iron‐promoted ligand‐to‐metal charge transfer process, triggering subsequent C−H pyrimidination. The substrates and catalysts are inexpensive and readily available, while the reaction conditions and procedures are simple without the need for external oxidants. This work provides a practical approach for synthesizing pyrimidine derivatives with high structural diversity.