One‐Pot Multicomponent Selective Synthesis of 5‐Trifluoromethyl Pyrimidine Derivatives-Reference-Cited by-同舟云学术

One‐Pot Multicomponent Selective Synthesis of 5‐Trifluoromethyl Pyrimidine Derivatives

Published:2024-06-16 Issue:12 Volume:366 Page:2715-2720
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Lou Dingyuan¹,Ding Yuxin¹,Jin Zhening¹,Huang Wenkai¹,Shi Yuan¹,Zhang Changjun¹,Xie Yuanyuan¹²³^ORCID

Affiliation:

1. College of Pharmaceutical Science Zhejiang University of Technology Hangzhou 310014 People's Republic of China

2. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of Technology Hangzhou 310014 People's Republic of China

3. Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education Key Laboratory of Pharmaceutical Engineering of Zhejiang Province Hangzhou 310014 People's Republic of China

Abstract

AbstractA one‐pot multi‐component reaction strategy for the selective synthesis of 5‐trifluoromethyl pyrimidine derivatives has been established. This method avoids the inherent selectivity challenges in direct pyrimidine trifluoromethylation. The reaction demonstrates tolerance to various functional groups, yielding 5‐trifluoromethyl pyrimidine derivatives with up to 80% yields. Moreover, the practicality of this method has been underscored through scale‐up reactions.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202400236

Reference44 articles.

2. Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis

3. Photoredox‐Catalyst‐Enabled para ‐Selective Trifluoromethylation of tert ‐Butyl Arylcarbamates

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