Affiliation:
1. National Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmaceutical Sciences & Institute of Materia Medica Shandong First Medical University & Shandong Academy of Medical Sciences 6699 Qingdao Road Jinan 250117 People's Republic of China
2. Shandong Center For Food and Drug Evaluation & Inspection 16122 Jingshi Road Jinan 250014 People's Republic of China
Abstract
AbstractTransition‐metal‐catalyzed hydroacylation of unsaturated substrates with aldehydes involving the formyl C(sp2)−H bond activation provides an expedient and efficient access to the carbonyl compounds such as ketones and esters, which are a class of important scaffolds in natural products and in drug development. Recently, extensive attention has been paid to the hydroacylation reactions of the components containing an alkenyl moiety that can trigger a regioselective transformation in the presence of a transition metal catalyst. In this review, we summarize the constructive endeavors in rhodium(I)‐catalyzed (formal) hydroacylation reactions from 2018, and the plausible pathway is also dissected to offer some insights into the reaction mechanism.
Funder
Natural Science Foundation of Shandong Province
Cited by
2 articles.
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