Traceless Directing Group Enabled One‐Pot Regiospecific Synthesis of 2,3‐Diaryl‐4‐Fluoropyrroles-Reference-Cited by-同舟云学术

Traceless Directing Group Enabled One‐Pot Regiospecific Synthesis of 2,3‐Diaryl‐4‐Fluoropyrroles

Published:2023-08-23 Issue:19 Volume:365 Page:3260-3264
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Wang Dan¹²,Tian Yu‐Ting¹²,Nie Jing¹²,Jasiński Marcin³,Tang Xiaodong¹²^ORCID,Ma Jun‐An¹²

Affiliation:

1. Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic Sciences Frontiers Science Center for Synthetic Biology (Ministry of Education) Tianjin Collaborative Innovation Centre of Chemical Science & Engineering Tianjin University Tianjin 300072 People's Republic of China

2. Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City Fuzhou 350207 People's Republic of China

3. Faculty of chemistry university of Lodz Tamka 12 91403 Łódź Poland

Abstract

AbstractWe describe a traceless group directed one‐pot regiospecific cycloaddition strategy to construct 4‐fluorinated pyrroles, which showcased promising anti‐inflammatory activity previously. By taking advantage of this protocol, a range of 4‐fluoropyrroles which are inaccessible via previous methods can be obtained, and a tentative reaction mechanism was proposed based on observed intermediates.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

Organic Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202300625

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