Affiliation:
1. Department of Chemistry Indian Institute of Technology Roorkee Roorkee 247667 India
Abstract
AbstractHerein, a direct C‐2 alkylation of Heterocyclic‐N‐oxides with alkyl amines as Katritzky salts via visible‐light induced deaminative approach was developed. Mechanistic studies revealed that Katritzky salts and base were involved to generate an EDA complex, which underwent intermolecular single electron transfer (SET) to give an alkyl radical intermediate. Finally, the alkyl radical intermediate further underwent‐addition with heterocyclic‐N‐oxide substrates to access the desired products with 63–94% yield. The method worked well with quinoline‐N‐oxides, pyridine‐N‐oxides, and benzopyrazine‐N‐oxides.
Funder
Uttarakhand State Council for Science and Technology
Science and Engineering Research Board
Cited by
5 articles.
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