Biochemical and Structural Characterization of an ( R )‐Selective Transaminase in the Asymmetric Synthesis of Chiral Hydroxy Amines-Reference-Cited by-同舟云学术

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Biochemical and Structural Characterization of an ( R )‐Selective Transaminase in the Asymmetric Synthesis of Chiral Hydroxy Amines

Published:2021-08-04 Issue:19 Volume:363 Page:4582-4589
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv. Synth. Catal.

Author:

Li Fulong¹,Liang Youxiang¹,Wei Yuwen¹,Zheng Yukun¹,Du Yan¹,Yu Huimin¹²³

Affiliation:

1. Department of Chemical Engineering Tsinghua University Beijing 100084 People's Republic of China

2. Key Laboratory of Industrial Biocatalysis the Ministry of Education Tsinghua University Beijing 100084 People's Republic of China

3. Center for Synthetic and Systems Biology Tsinghua University Beijing 100084 People's Republic of China

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202100636

Reference52 articles.

1. Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

2. Use of ω-Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

3. Comparative replication capacity of raltegravir-resistant strains and antiviral activity of the new-generation integrase inhibitor dolutegravir in human primary macrophages and lymphocytes

4. Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

5. Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis

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1. Engineering an (R)-selective transaminase for asymmetric synthesis of (R)-3-aminobutanol;Bioorganic Chemistry;2024-05

2. Protein engineering of transaminase facilitating enzyme cascade reaction for the biosynthesis of azasugars;iScience;2024-03

3. Expanding the Application of Alcohol Dehydrogenases in Pharmaceutical Chemistry: A Focus on Piperidone Synthesis;ChemCatChem;2024-02-29

4. Biocatalytic asymmetric ring-opening of meso-epoxides to enantiopure cyclic trans-β-amino alcohols involving a key amine transaminase;Green Chemistry;2024

5. Redesigning an (R)-Selective Transaminase for the Efficient Synthesis of Pharmaceutical N-Heterocyclic Amines;ACS Catalysis;2022-12-19

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