Affiliation:
1. Dipartimento di Scienze Farmaceutiche Sezione di Chimica Generale e Organica “A. Marchesini” Università degli Studi di Milano Via G. Venezian 21 20133 Milano Italy
2. Dipartimento di Chimica Università degli Studi di Milano Via C. Golgi 19 20133 Milano Italy
Abstract
AbstractA photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric indole‐fused 1,4‐diazepinones characterized by a N−C(aryl) axial chirality in yields ranging from 51 to 99%.