Affiliation:
1. Faculty of Life Science and Technology Kunming University of Science and Technology Kunming 650500 People's Republic of China
Abstract
AbstractDecarbonylative and dehydrogenative cascade annulation of aldehydes with N‐(o‐cyanobiaryl)acrylamides was developed for the synthesis of a broad spectrum of alkyl‐ and carbonyl‐substituted pyrido[4,3,2‐gh]phenanthridines. Secondary and tertiary aldehydes can undergo the decarbonylative cascade under DTBP/malonic acid conditions, while aryl, primary, and secondary aldehydes can undergo dehydrogenative reaction under TBHP system. Such transformations were triggered by alkyl and acyl radicals, and the annulations were accomplished through intramolecular additions of carbon‐centered radical to nitrile group and iminyl radical to aromatic ring.
Funder
National Natural Science Foundation of China
Cited by
1 articles.
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