Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies

Author:

Close Edward J.12,Salm Jeffrey R.3,Iskra Timothy3,Sørensen Eva2,Bracewell Daniel G.1

Affiliation:

1. The Advanced Centre for Biochemical Engineering, Department of Biochemical EngineeringUniversity College LondonTorrington PlaceLondonWC1E 7JEUK

2. Centre for Process Systems Engineering, Department of Chemical EngineeringUniversity College LondonTorrington PlaceLondonUK

3. PfizerAndoverMassachusetts

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference33 articles.

1. Image processing with Image;Abramoff MD;J Biophotonics Int,2004

2. Protein adsorption and transport in cation exchangers with a rigid backbone matrix with and without polymeric surface extenders

3. Demonstration of the use of windows of operation to visualise the effects of fouling on the performance of a chromatographic step;Boushaba R;Biotechnol Prog,2011

4. Impact of clarification strategy on chromatographic separations: Pre-processing of cell homogenates

5. Effect of fouling on the capacity and breakthrough characteristics of a packed bed ion exchange chromatography column

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