Plasma biomarkers of Alzheimer's disease and related dementias in American Indians: The Strong Heart Study

Author:

Suchy‐Dicey Astrid M.1234ORCID,Longstreth W. T.5,Rhoads Kristoffer45,Umans Jason6,Buchwald Dedra3,Grabowski Thomas45,Blennow Kaj78,Reiman Eric9,Zetterberg Henrik78

Affiliation:

1. Washington State University Elson S Floyd College of Medicine Spokane Washington USA

2. Huntington Medical Research Institutes Pasadena California USA

3. Washington State University Institute for Research and Education to Address Community Health Seattle Washington USA

4. University of Washington Alzheimer's Disease Research Center Seattle Washington USA

5. Department of Neurology University of Washington Seattle Washington USA

6. MedStar Health Research Institute Hyattsville Maryland USA

7. Institute of Neuroscience and Physiology the Sahlgrenska Academy at University of Gothenburg Mölndal Sweden

8. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

9. Banner Alzheimer's Institute Phoenix Arizona USA

Abstract

AbstractINTRODUCTIONIdentification of Alzheimer's disease (AD) needs inexpensive, noninvasive biomarkers, with validation in all populations.METHODSWe collected plasma markers in older American Indian individuals: phosphorylated‐tau181 (pTau181); amyloid‐beta (Aβ) 40,42; glial fibrillary acidic protein (GFAP); and neurofilament light chain (NfL). Plasma markers were analyzed for discriminant properties with cognitive status and etiology using receiver operating characteristic (ROC) analysis.RESULTSPTau181, GFAP, NfL plasma values were significantly associated with cognition, but Aβ were not. Discriminant performance was moderate for individual markers, with pTau181, GFAP, NfL performing best, but an empirically selected panel of markers (age, sex, education, pTau181, GFAP, NfL, Aβ4240 ratio) had excellent discriminant performance (AUC > 0.8).DISCUSSIONIn American Indian individuals, pTau181 and Aβ values suggested more common pathology than in majority populations. Aβ was less informative than in other populations; however, all four markers were needed for a best‐performing dementia diagnostic model. These data validate utility of AD plasma markers, while suggesting population‐specific diagnostic characteristics.

Funder

National Institutes of Health

Publisher

Wiley

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