Population pharmacokinetics of TC-5214, a nicotinic channel modulator, in phase I and II clinical studies-Reference-Cited by-同舟云学术

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Population pharmacokinetics of TC-5214, a nicotinic channel modulator, in phase I and II clinical studies

Published:2014-01-16 Issue:6 Volume:54 Page:707-718
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Xu Hongmei¹,Henningsson Anja²,Alverlind Sofie³,Tummala Raj⁴,Toler Steven⁵,Beaver Jessica S.⁵,Al-Huniti Nidal¹

Affiliation:

1. Quantitative Clinical Pharmacology; AstraZeneca Pharmaceuticals; Wilmington DE USA

2. Quantitative Clinical Pharmacology; AstraZeneca AB; Södertälje Sweden

3. Former Clinical Pharmacology and Pharmacometrics; AstraZeneca AB; Södertälje Sweden

4. Inflammation, Neuroscience and Respiratory GMed; AstraZeneca Pharmaceuticals; Wilmington DE USA

5. Targacept, Inc.; Winston-Salem NC USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference21 articles.

1. TC-5214(S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity;Lippiello;CNS Neurosci Ther,2008

2. Mecamylamine-a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders;Bacher;Expert Opin Pharmacother,2009

3. The potential of the nicotinic channel blocker TC-5214 as augmentation treatment in patients with major depression;Dunbar;Eur Neuropsychopharmacol,2010

4. Prediction of creatinine clearance from serum creatinine;Cockcroft;Nephron,1976

5. Pharmacokinetics of gentamicin in 957 patients with varying renal function dosed once daily;Kirkpatrick;Br J Clin Pharmacol,1999

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1. Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate;Bioanalysis;2018-08-01

2. Drug-disease modeling in the pharmaceutical industry - where mechanistic systems pharmacology and statistical pharmacometrics meet;European Journal of Pharmaceutical Sciences;2017-11

3. Pharmacokinetics and pharmacodynamics of oral mecamylamine – development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation;Journal of Psychopharmacology;2016-12-09

4. Evaluation of Aztreonam Dosing Regimens in Patients With Normal and Impaired Renal Function: A Population Pharmacokinetic Modeling and Monte Carlo Simulation Analysis;The Journal of Clinical Pharmacology;2016-09-14

5. Safety and Tolerability of Dexmecamylamine (TC-5214) Adjunct to Ongoing Antidepressant Therapy in Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Therapy;Journal of Clinical Psychopharmacology;2015-02

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