Distribution of regional lymph lode metastasis in unilateral nasopharyngeal carcinoma and the suggestions for selective prophylactic irradiation with intensity‐modulated radiotherapy-Reference-Cited by-同舟云学术

Distribution of regional lymph lode metastasis in unilateral nasopharyngeal carcinoma and the suggestions for selective prophylactic irradiation with intensity‐modulated radiotherapy

Published:2023-10-25 Issue:21 Volume:12 Page:20511-20520
ISSN:2045-7634
Container-title:Cancer Medicine
language:en
Short-container-title:Cancer Medicine

Author:

Lin Feifei¹²^ORCID,Qiu Zichen¹^ORCID,Xie Dehuan³,Zhou Xiong¹,Wang Lei⁴,Wu Zheng⁵,Cheng Wanqin⁶,Lyu Shaowen⁷,Su Yong¹^ORCID,Tao Yalan¹

Affiliation:

1. Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou P.R. China

2. Department of Radiation Oncology Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China

3. Department of Radiotherapy Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangdong Guangzhou P.R. China

4. Department of Radiation Oncology The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center) Kunming P.R. China

5. Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital 14 of Xiangya School of Medicine Central South University Changsha P.R. China

6. Department of Radiation Oncology Shunde Hospital of Southern Medical University Foshan P. R. China

7. Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands

Abstract

AbstractPurposeTo address the regional lymph node (RLN) distribution and the long‐term efficacy in unilateral nasopharyngeal carcinoma (NPC), providing elective irradiation for RLN with intensity‐modulated radiotherapy (IMRT).MethodsThe involvement of clinical data of 136 patients with unilateral NPC, who underwent IMRT from November 2003 to December 2020 were analyzed retrospectively. The therapeutic effect and failure pattern of RLN metastasis were evaluated.ResultsOf 57.1% patients have bilateral RLN metastasis. The rate of contralateral RLNs metastasis is lower than that of ipsilateral RLNs. Contralateral RLN metastasis mainly occurs in level VIIa (39.0%) and II (38.2%). While level IVa is only 0.7%, and none of RLN metastasis was found in level IVb and Va. The median follow‐up was 70 months, and the 3‐, 5‐and 10‐year regional recurrence‐free survival (RRFS) were 94.1%, 93.1%, and 93.1%, respectively.ConclusionRoutine prophylactic irradiation may not include contralateral lower neck LN and level Va for N0‐1 unilateral NPC.

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.6614

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