Hybrid Bacteria System with Nanomaterials for Tumor Therapy

Author:

Zhang Qinyi12,Ma Xiaotu12,Zhao Xiao12ORCID

Affiliation:

1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China 11 Beiyitiao Zhongguancun Beijing 100190 China

2. Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China

Abstract

Recently, bacteria‐mediated therapy has been widely applied for tumor treatments owing to some inherent features of bacteria. With further advancements in genetic engineering and nanotechnology, natural bacteria are endowed with extra capacities of rational genetic reprogramming, spatiotemporally precise manipulation, and some other exogenous characteristics. Hybrid bacteria systems leverage versatile nanomaterials to modify the surface of bacteria, which exhibit great potential in solving the existed problems of traditional bacteria therapy, further greatly improving the tumor therapeutic efficacy. Therefore, hybrid bacteria–based therapeutic platforms present a promising strategy for tumor therapy, which raise increasing attentions. In this review, hybrid bacteria systems for tumor therapy based on different types of chassis bacteria and other related organisms are introduced, and methodologies of nanomaterial‐modified bacteria are systemically expounded. Moreover, the promises of hybrid bacteria as drug delivery vesicles for cancer therapy, other disease therapy, bioimaging, and diagnosis are further discussed, followed by the elaboration on their perspectives and challenges in clinical translation.

Funder

Natural Science Foundation of Beijing Municipality

Beijing Nova Program

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Medicine

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