A digital microfluidic chip with programmable open system actuation and enhanced optical annealing with near‐infrared light

Abstract

AbstractThis work investigates a digital microfluidic chip and presents an advancement to microfluidic optical annealing methods through the application of whispering gallery mode (WGM) with near infrared excitation. Establishing a microfluidic chip with point‐of‐care capabilities, including actuation and annealing, has proven to be important. Unfortunately, poor heat absorption due to the long optical penetration depth of near infrared light creates scaling limitations for applications in optical‐based microfluidics. Through the application of WGM, the interaction length between the droplet and light is increased beyond the droplet diameter to improve heating and optical absorption. This is supported by finite‐difference time‐domain electromagnetic simulations and experimental results showing a greatly improved temperature change. Such a system is implemented in an open system digital microfluidic chip, to facilitate annealing via side illumination of droplets. The open system digital microfluidic chip is programmable for droplet actuation. The fundamental experiment of preprogrammed actuation of microdroplets is demonstrated in a 36 electrode grid. The results of annealing and actuation show potential for implementation in point‐of‐care microfluidic devices.