Assessment of circulating apoE4 levels from dried blood spot samples in a large survey setting

Author:

Borbye‐Lorenzen Nis1ORCID,Deza‐Lougovski Yacila I.23ORCID,Holmgaard Solveig1,Weiss Luzia M.3,Bækvad‐Hansen Marie1ORCID,Skogstrand Kristin1ORCID,Rieckmann Anna23ORCID,Börsch‐Supan Axel345ORCID,Börsch‐Supan Martina46ORCID

Affiliation:

1. Department of Congenital Disorders Center for Neonatal Screening, Statens Serum Institut Copenhagen Denmark

2. Institute of Psychology University of the Bundeswehr München Neubiberg Germany

3. Max Planck Institute for Social Law and Social Policy Munich Germany

4. The Munich Research Institute for the Economics of Aging and SHARE Analyses (MEA) Munich Germany

5. National Bureau of Economic Research Cambridge Massachusetts USA

6. Survey of Health, Ageing and Retirement in Europe (SHARE Biomarker Project) Munich Germany

Abstract

AbstractINTRODUCTIONThe apolipoprotein E (APOE) ε4 allele is associated with high risk for Alzheimer's disease. It is unclear whether individual levels of the circulating apoE4 protein in ε4 carriers confer additional risk. Measuring apoE4 protein levels from dried blood spots (DBS) has the potential to provide information on genetic status as well as circulating levels and to include these measures in large survey settings.METHODSWe developed a multiplex immunoassay to detect apoE4 protein levels in DBS from 15,974 participants, aged 50+ from Wave 6 of the Survey of Health, Ageing and Retirement in Europe (SHARE).RESULTSThe apoE4 protein signal was presented in two separable distributions. One distribution corresponded to carriers of at least one copy of the ε4 allele. Fieldwork cofounders affected protein levels but did not explain individual differences.DISCUSSIONFuture research should investigate how genotype and apoE4 level interact with lifestyle and other variables to impact cognitive aging.

Funder

National Institute on Aging

Max-Planck-Gesellschaft

European Commission

Horizon 2020

Publisher

Wiley

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