Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome-Reference-Cited by-同舟云学术

Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome

Published:2024-01 Issue:1 Volume:16 Page:
ISSN:2352-8729
Container-title:Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
language:en
Short-container-title:Alz & Dem Diag Ass & Dis Mo

Author:

DiProspero Natalie¹²,Sathishkumar Mithra¹²,Janecek John¹²,Smith Anna¹²,McMillan Liv¹²,Petersen Melissa³,Tustison Nicholas¹⁴,Keator David B.⁵,Doran Eric⁶,Hom Christy L.⁶,Nguyen Dana⁶,Andrews Howard⁷,Krinsky‐McHale Sharon⁸,Brickman Adam M.⁸⁹,Rosas H. Diana¹⁰,Lai Florence¹⁰,Head Elizabeth²¹¹,Mapstone Mark²¹²,Silverman Wayne⁶,Lott Ira T.⁶,O'Bryant Sid³,Yassa Michael A.¹²⁵¹²

Affiliation:

1. Department of Neurobiology and Behavior School of Biological Sciences University of California Irvine California USA

2. Center for the Neurobiology of Learning and Memory University of California Irvine California USA

3. Institute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA

4. Department of Radiology University of Virginia Charlottesville Virginia USA

5. Department of Psychiatry and Behavioral Sciences School of Medicine University of California Irvine California USA

6. Department of Pediatrics School of Medicine University of California Irvine California USA

7. Department of Psychiatry College of Physicians and Surgeons Columbia University New York New York USA

8. Department of Neurology College of Physicians and Surgeons Columbia University New York New York USA

9. Taub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons Columbia University New York New York USA

10. Department of Neurology Massachusetts General Hospital Boston Massachusetts USA

11. Department of Pathology School of Medicine University of California Irvine California USA

12. Department of Neurology School of Medicine University of California Irvine California USA

Abstract

AbstractINTRODUCTIONVirtually all people with Down syndrome (DS) develop neuropathology associated with Alzheimer's disease (AD). Atrophy of the hippocampus and entorhinal cortex (EC), as well as elevated plasma concentrations of neurofilament light chain (NfL) protein, are markers of neurodegeneration associated with late‐onset AD. We hypothesized that hippocampus and EC gray matter loss and increased plasma NfL concentrations are associated with memory in adults with DS.METHODST1‐weighted structural magnetic resonance imaging (MRI) data were collected from 101 participants with DS. Hippocampus and EC volume, as well as EC subregional cortical thickness, were derived. In a subset of participants, plasma NfL concentrations and modified Cued Recall Test scores were obtained. Partial correlation and mediation were used to test relationships between medial temporal lobe (MTL) atrophy, plasma NfL, and episodic memory.RESULTSHippocampus volume, left anterolateral EC (alEC) thickness, and plasma NfL were correlated with each other and were associated with memory. Plasma NfL mediated the relationship between left alEC thickness and memory as well as hippocampus volume and memory.DISCUSSIONThe relationship between MTL gray matter and memory is mediated by plasma NfL levels, suggesting a link between neurodegenerative processes underlying axonal injury and frank gray matter loss in key structures supporting episodic memory in people with DS.

Publisher

Wiley

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