Walking energetics and white matter hyperintensities in mid‐to‐late adulthood

Author:

Dougherty Ryan J.12,Wanigatunga Amal A.23,An Yang4,Tian Qu4,Simonsick Eleanor M.4,Albert Marilyn S.1,Resnick Susan M.4,Schrack Jennifer A.23

Affiliation:

1. Department of Neurology Johns Hopkins School of Medicine Baltimore Maryland USA

2. Center on Aging and Health Johns Hopkins University Baltimore Maryland USA

3. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

4. Intramural Research Program National Institute on Aging Baltimore Maryland USA

Abstract

AbstractINTRODUCTIONWhite matter hyperintensities (WMHs) increase with age and contribute to cognitive and motor function decline. Energy costs for mobility worsen with age, as the energetic cost of walking increases and energetic capacity declines. We examined the cross‐sectional associations of multiple measures of walking energetics with WMHs in mid‐ to late‐aged adults.METHODSA total of 601 cognitively unimpaired adults (mean age 66.9 ± 15.3 years, 54% women) underwent brain magnetic resonance imaging scans and completed standardized slow‐ and peak‐paced walking assessments with metabolic measurement (V̇O2). T1‐weighted scans and fluid‐attenuated inversion recovery images were used to quantify WMHs. Separate multivariable linear regression models examined associations adjusted for covariates.RESULTSLower slow‐paced V̇O2 (B = 0.07; P = 0.030), higher peak‐paced V̇O2 (B = –0.10; P = 0.007), and lower cost‐to‐capacity ratio (B = .12; P < 0.0001) were all associated with lower WMH volumes.DISCUSSIONThe cost‐to‐capacity ratio, which describes the percentage of capacity required for ambulation, was the walking energetic measure most strongly associated with WMHs.

Funder

National Institute on Aging

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

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