Complete hematologic response after belinostat treatment and allogeneic stem cell transplantation for multiple relapsed/refractory angioimmunoblastic T‐cell lymphoma: A case report

Author:

Camus Vincent1ORCID,Etancelin Pascaline2,Drieux Fanny3,Veresezan Elena‐Liana3,Picquenot Jean‐Michel3,Penther Dominique2,Viennot Mathieu4,Ruminy Philippe4,Contentin Nathalie1,Lemasle Emilie1,Leprêtre Stéphane1,Dubois Sydney1,Penichoux Juliette1,Stamatoullas Aspasia1,Zduniak Alexandra1,Lanic Hélène1,Jardin Fabrice1

Affiliation:

1. Department of Hematology Centre Henri Becquerel Rouen France

2. Department of Genetic Oncology Centre Henri Becquerel Rouen France

3. Department of Pathology Centre Henri Becquerel Rouen France

4. INSERM U1245 Centre Henri Becquerel Rouen France

Abstract

Key Clinical MessageThis case report highlights the potential of belinostat for the treatment of relapsed/refractory peripheral T‐cell lymphomas, for which effective therapies are still scarce.AbstractPeripheral T‐cell lymphomas have an aggressive disease course associated with poor outcomes. We report a young patient with highly pretreated relapsed/refractory nodal follicular helper T‐cell lymphoma (angioimmunoblastic‐type [nTFHL‐AI]), who successfully received an allogeneic stem cell transplantation following belinostat therapy. The complete hematologic response achieved has lasted more than 2 years.

Publisher

Wiley

Subject

General Medicine

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