Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended‐release tablets-Reference-Cited by-同舟云学术

Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended‐release tablets

Published:2019-08-07 Issue:8 Volume:40 Page:282-293
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm Drug Dispos

Author:

Inoue Yuji¹^ORCID,Morita Hirotoshi²,Nozawa Kohei³,Kanazu Takushi¹

Affiliation:

1. Drug Metabolism & PharmacokineticsShionogi & Co., Ltd., Toyonaka Osaka Japan

2. Analytical Chemistry & BioanalysisShionogi TechnoAdvance Research Co., Ltd., Toyonaka Osaka Japan

3. Drug Development Solutions CenterSekisui Medical Co., Ltd., Tokai Ibaraki Japan

Funder

Shionogi

Shire

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bdd.2201

Reference13 articles.

1. Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery

2. European Medicines Agency (EMA). (2015).Intuniv (guanfacine). [Online] Available at:http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003759/human_med_001910.jsp&mid=WC0b01ac058001d124. Accessed on 17 January 2019.

3. Food and Drug Administration (FDA). (2009).Drug approval package: Intuniv (guanfacine) extended‐release 1 mg 2 mg 3 mg and 4 mg tablets. [Online] Available at:https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022037_intuniv_toc.cfm. Accessed on 17 January 2019.

4. Food and Drug Administration (FDA). (2016).Guidance for Industry. Safety Testing of Drug Metabolites. [Online] Available at:http://www.fda.gov/ucm/groups/fdagov‐public/@fdagov‐drugs‐gen/documents/document/ucm079266.pdf. Accessed on 17 January 2019.

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