Pharmacokinetics and Metabolism of the Antimalarial Piperaquine After Intravenous and Oral Single Doses to the Rat-Reference-Cited by-同舟云学术

Pharmacokinetics and Metabolism of the Antimalarial Piperaquine After Intravenous and Oral Single Doses to the Rat

Published:2008-08 Issue:8 Volume:97 Page:3400-3410
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Tarning J.,Lindegardh N.,Sandberg S.,Day N.J.P.,White N.J.,Ashton M.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference15 articles.

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3. Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria;Denis;Clin Infect Dis,2002

4. Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria;Karunajeewa;Br J Clin Pharmacol,2004

5. An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria;Tangpukdee;Southeast Asian J Trop Med Public Health,2005

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1. The antiplasmodial activity of the carboxylic acid metabolite of piperaquine and its pharmacokinetic profiles in healthy volunteers;Journal of Antimicrobial Chemotherapy;2023-11-15

2. The Effect of Retroconversion Metabolism of N-oxide Metabolites by Intestinal Microflora on Piperaquine Elimination in Mice, as well as in Humans Predicted Using a PBPK Model;Current Drug Metabolism;2023-02

3. Metabolism is not a Major Contributor to the Toxicity of Piperaquine, a Long-acting Antimalarial Agent in Artemisinin-based Combination Therapy;Current Drug Metabolism;2021-12-15

4. Metabolic Retroversion of Piperaquine (PQ) via Hepatic Cytochrome P450–Mediated N-Oxidation and Reduction: Not an Important Contributor to the Prolonged Elimination of PQ;Drug Metabolism and Disposition;2021-03-05

5. Metabolism of Piperaquine to Its Antiplasmodial Metabolites and Their Pharmacokinetic Profiles in Healthy Volunteers;ANTIMICROB AGENTS CH;2018