Affiliation:
1. Health Insurance Review and Assessment Service Wonju‐si Republic of Korea
2. Chungbuk National University Chungcheongbuk‐do Republic of Korea
3. Korea University Seoul Republic of Korea
4. Sungshin Women's University Woonjung Green Campus Seoul Republic of Korea
5. Seojeong University Yangju‐si Republic of Korea
6. Ewha Womans University Seoul Republic of Korea
Abstract
ObjectivePopulation‐based studies of the familial aggregation of gout are scarce, and gene/environment interactions are not well studied. This study was undertaken to evaluate the familial aggregation of gout as well as assess interactions between family history and obesity or alcohol consumption on the development of gout.MethodsUsing the Korean National Health Insurance database, which includes information regarding familial relationships and risk factor data, we identified 5,524,403 individuals from 2002 to 2018. Familial risk was calculated using hazard ratios (HRs) with 95% confidence intervals (95% CIs) to compare the risk in individuals with and those without affected first‐degree relatives. Interactions between family history and obesity/alcohol consumption were assessed on an additive scale using the relative excess risk due to interaction (RERI).ResultsIndividuals with a gout‐affected first‐degree relative had a 2.42‐fold (95% CI 2.39, 2.46) increased risk of disease compared to those with unaffected first‐degree relatives. Having both a family history of gout and being either overweight or having moderate alcohol consumption was associated with a markedly increased risk of disease, with HRs of 4.39 (95% CI 4.29, 4.49) and 2.28 (95% CI 2.22, 2.35), respectively, which exceeded the sum of their individual risks but was only statistically significant in overweight individuals (RERI 0.96 [95% CI 0.85, 1.06]). Obese individuals (RERI 1.88 [95% CI 1.61, 2.16]) and heavy drinkers (RERI 0.36 [95% CI 0.20, 0.52]) had a more prominent interaction compared to overweight individuals and moderate drinkers, suggesting a dose‐response interaction pattern.ConclusionOur findings indicate the possibility of an interaction between gout‐associated genetic factors and obesity/alcohol consumption.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献