Reconstruction of rearranged T‐cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T‐cell prolymphocytic leukemia

Author:

Patil Paurnima1,Cieslak Agata2,Bernhart Stephan H.3,Toprak Umut H.456,Wagener Rabea17,López Cristina17,Wiehle Laura1,Bens Susanne17,Altmüller Janine8,Franitza Marek8,Scholz Ingrid9,Jayne Sandrine10,Ahearne Matthew J.10,Scheffold Annika11,Jebaraj Billy M. C.11,Schneider Christof11,Costa Dolors12,Braun Till13,Schrader Alexandra13,Campo Elias12,Dyer Martin J. S.10,Nürnberg Peter8,Dürig Jan14,Johansson Patricia14,Böttcher Sebastian15,Schlesner Matthias4,Herling Marco13,Stilgenbauer Stephan11,Macintyre Elizabeth2,Siebert Reiner17

Affiliation:

1. Institute of Human Genetics University of Ulm and University of Ulm Medical Center Ulm Germany

2. Diagnostic Haematology, Necker‐Enfants Malades Hospital, Assistance Publique Hôpitaux de Paris Université Paris Descartes Sorbonne Cité, Institut Necker‐Enfants Malades (INEM), Institut national de recherche médicale (INSERM) Paris France

3. Interdisciplinary Center for Bioinformatics, Transcriptome Bioinformatics University of Leipzig Leipzig Germany

4. Bioinformatics and Omics Data Analytics, German Cancer Research Center, Faculty of Biosciences Heidelberg University Heidelberg Germany

5. Division Neuroblastoma Genomics, German Cancer Research Center (DKFZ) Heidelberg Germany

6. Hopp‐Children's Cancer Center at the NCT Heidelberg (KiTZ) Heidelberg Germany

7. Institute for Human Genetics Christian‐Albrechts‐University Kiel and University Hospital Schleswig‐Holstein Kiel Germany

8. Cologne Center for Genomics, Center for Molecular Medicine Cologne University of Cologne Cologne Germany

9. Omics IT and Data Management Core Facility German Cancer Research Center Heidelberg Germany

10. Ernest and Helen Scott Haematological Research Institute, Department of Cancer Studies University of Leicester Leicester UK

11. Department of Internal Medicine III University of Ulm Ulm Germany

12. Haematopathology Section, Hospital Clínic, Institut d'Investigaciones Biomèdiques August Pi I Sunyer (IDIBAPS) University of Barcelona Barcelona Spain

13. Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, Deutsche CLL Studiengruppe (DCLLSG), Excellence Cluster for Cellular Stress Response and Aging‐Associated Diseases (CECAD), and Center of Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany

14. Department of Hematology, University Hospital Essen University of Duisburg‐Essen Essen Germany

15. Department III of Internal Medicine University Hospital Rostock Rostock Germany

Funder

Deutsche Forschungsgemeinschaft

Fritz Thyssen Foundation

CMMC, UoC

Publisher

Wiley

Subject

Cancer Research,Genetics

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