Trastuzumab‐induced toxic epidermal necrolysis in a Her‐2‐positive metastatic breast cancer patient—A rare case report

Author:

Ferdause Jannatul1,Momtahena Sura Jukrup1,Karim Rubama1,Chowdhury Aditi Paul1,Hossain Nowshin Taslima1,Islam Md Ariful1,Habib Maruf Bin2,Kadir A. K. M. Shafiul3,Haque Md Ariful456ORCID

Affiliation:

1. Ahsania Mission Cancer and General Hospital Dhaka Bangladesh

2. Department of Medicine Ahsania Mission Medical College Dhaka Bangladesh

3. Quest Bangladesh Biomedical Research Center Dhaka Bangladesh

4. Department of Public Health Atish Dipankar University of Science and Technology Dhaka Bangladesh

5. Voice of Doctors Research School Dhaka Bangladesh

6. Department of Orthopaedic Surgery Yan'an Hospital Affiliated to Kunming Medical University Kunming Yunnan China

Abstract

Key Clinical MessageToxic Epidermal Necrolysis (TEN) is a rare, but potentially fatal mucocutaneous reaction, that may occur due to an immunologic response to certain medications. However, TEN triggered by Trastuzumab is extremely rare. Early diagnosis, recognition, and prompt cessation of the offending drugs and initiation of steroid therapy with supportive management are the most important actions for managing TEN. Although rare, it is important to be vigilant about this potential adverse reactions associated with trastuzumab to ensure patient safety and contribute to better outcomes.

Publisher

Wiley

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1. Trastuzumab;Reactions Weekly;2024-08-24

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