Unusual Distribution Kinetics of Gadoxetate in Healthy Human Subjects Genotyped for OATP1B1: Application of Population Analysis and a Minimal Physiological‐Based Pharmacokinetic Model
Author:
Affiliation:
1. Department of Pharmacology Martin Luther University Halle‐Wittenberg Halle Germany
2. Department of Clinical Pharmacology, Center of Drug Absorption and Transport (C_DAT) University Medicine Greifswald Germany
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1762
Reference30 articles.
1. Interpretation of General Measures of Distribution Kinetics in Terms of a Mammillary Compartmental Model
2. Residence Time Dispersion as a General Measure of Drug Distribution Kinetics: Estimation and Physiological Interpretation
3. Primovist, Eovist: What to expect?
4. Characterization of the Intestinal and Hepatic Uptake/Efflux Transport of the Magnetic Resonance Imaging Contrast Agent Gadolinium-Ethoxylbenzyl-Diethylenetriamine-Pentaacetic Acid
5. Visualization of Hepatic Uptake Transporter Function in Healthy Subjects by Using Gadoxetic Acid–enhanced MR Imaging
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3. Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats;Molecular Pharmaceutics;2021-07-20
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