Affiliation:
1. School of Chemical Engineering and Chemistry Harbin Institute of Technology Harbin China
2. Dairy Nutrition and Function, Key Laboratory of Sichuan Province, New Hope Dairy Company Limited Chengdu China
3. Jiangsu HOWYOU Biotechnology Co. Ltd Qidong China
Abstract
AbstractBACKGROUNDParaprobiotics and postbiotics have shown potential in the treatment of ulcerative colitis (UC). However, their in vivo application is still in its infancy and their mechanisms of action are not well understood.RESULTSHere, we investigated the mitigation effects of Limosilactobacillus fermentum HF06‐derived paraprobiotic (6‐PA) and postbiotic (6‐PS) on dextran sulfate sodium induced UC and the potential mechanisms. Results indicated that the administration of 6‐PA and 6‐PS resulted in the inhibition of weight loss and colon shortening in mice with UC. Furthermore, they led to a significant reduction in both fecal moisture content and the levels of proinflammatory cytokines and oxidative stress in the intestine of the mice. 6‐PA and 6‐PS treatment strengthened the intestinal mucosal barrier by dramatically upregulating the levels of zonula occludens‐1 and occludin proteins. In addition, 6‐PA and 6‐PS restored intestinal dysbiosis by regulating abundances of certain bacteria, such as Bifidobacterium, Faecalibaculum, Muribaculaceae, Corynebacterium, Escherichia‐Shigella and Clostridium_sensu_stricto_1, and regulated the level of short‐chain fatty acids.CONCLUSIONThese findings illustrated for the first time that L. fermentum HF06‐derived paraprobiotic and postbiotic enhanced the intestinal barrier function, and restored gut microbiota alterations. © 2023 Society of Chemical Industry.
Funder
Natural Science Foundation of Sichuan Province
Subject
Nutrition and Dietetics,Agronomy and Crop Science,Food Science,Biotechnology
Cited by
6 articles.
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