Affiliation:
1. Department of Cancer Control and Population Health National Cancer Center Graduate School of Cancer Science and Policy Goyang‐si South Korea
2. Center for Population Health Sciences Hanoi University of Public Health Hanoi Vietnam
3. Division of Cancer Prevention National Cancer Center Goyang South Korea
4. Hanoi Medical University Hanoi Vietnam
Abstract
AbstractAimTo estimate the risk of cancer incidence and mortality among patients with alcoholic liver disease in South Korea.MethodsA matched cohort study was conducted, including 1,042,185 men (alcoholic liver disease cases: 208,437; controls: 833,748) and 100,400 women (alcoholic liver disease cases: 20,080; controls: 80,320), matched for sex, age, smoking, alcohol consumption, and body mass index at a 1:4 ratio. The risk of cancer incidence and mortality in the alcoholic liver disease group was assessed using Cox proportional hazards regression models.ResultsBoth men and women with alcoholic liver disease had an elevated risk of all‐cancer and liver cancer incidence and mortality in comparison with the control group. In men, alcoholic liver disease was associated with a significantly higher risk of development of 10 cancer types, including lip, oral cavity, and pharynx; esophagus; liver; gallbladder and biliary tract; pancreas; larynx; lung; kidney; thyroid gland; and leukemia. Subgroup analysis by hepatitis B and C infection showed increased hazard ratios of all cancer incidences and mortality in the alcoholic liver disease group, regardless of hepatitis B or C infection status. In both sexes, a higher number and more years of hospital or clinic visits for alcoholic liver disease were associated with an increased risk of incidence and mortality from all cancers and liver cancer. A more profound dose–response relationship between alcoholic liver disease and alcohol consumption was observed in women than in men.ConclusionsOur findings emphasize the need for a clinical surveillance program and the early detection of cancer in patients with alcoholic liver disease.
Subject
Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology