Unexpected ethical dilemmas in sex assignment in 46,XY DSD due to 5-alpha reductase type 2 deficiency

Author:

Byers Heather M.1ORCID,Mohnach Lauren H.2,Fechner Patricia Y.34,Chen Ming5,Thomas Inas H.5,Ramsdell Linda A.6,Shnorhavorian Margarett7,McCauley Elizabeth A.8ORCID,Amies Oelschlager Anne-Marie E.9,Park John M.10,Sandberg David E.11ORCID,Adam Margaret P.16ORCID,Keegan Catherine E.12ORCID

Affiliation:

1. Division of Medical Genetics; University of Washington; Seattle Washington

2. DSD Program; Department of Pediatrics; University of Michigan; Ann Arbor Michigan

3. Division of Endocrinology; Seattle Children's Hospital; Seattle Washington

4. Division of Pediatric Psychology; Seattle Children's Hospital; Seattle Washington

5. Division of Endocrinology; Department of Pediatrics; University of Michigan; Ann Arbor Michigan

6. Division of Genetic Medicine; Seattle Children's Hospital; Seattle Washington

7. Division of Urology; Seattle Children's Hospital; Seattle Washington

8. Department of Psychiatry and Behavior Medicine; University of Washington; Seattle Washington

9. Division of Adolescent Gynecology; Seattle Children's Hospital; Seattle Washington

10. Department of Urology; University of Michigan; Ann Arbor Michigan

11. Division of Pediatric Psychology; Department of Pediatrics; University of Michigan; Ann Arbor Michigan

12. Division of Genetics; Department of Pediatrics; University of Michigan; Ann Arbor Michigan

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institutes of Health

Publisher

Wiley

Subject

Genetics(clinical),Genetics

Reference21 articles.

1. Recognition of 5α-reductase-2 deficiency in an adult female 46XY DSD clinic;Berra;European Journal of Endocrinology,2011

2. Gender change in 46,XY persons with 5alpha-reductase-2 deficiency and 17beta-hydroxysteroid dehydrogenase-3 deficiency;Cohen-Kettenis;Archives of Sexual Behavior,2005

3. DSD due to 5α-reductase 2 deficiency-From diagnosis to long-term outcome;Costa;Seminars in Reproductive Medicine,2012

4. Disability Rights Washington. Devaluing people with disabilities: Medical procedures that violate civil rights 2012 http://www.disabilityrightswa.org/devaluing-people-disabilities

5. Consensus in guidelines for evaluation of DSD by the texas children's hospital multidisciplinary gender medicine team;Douglas;International Journal of Pediatric Endocrinology,2010

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