Affiliation:
1. Laboratory of Advanced Theranostic Materials and Technology, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo China
2. University of Chinese Academy of Sciences Beijing China
3. International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering Nanjing Forestry University Nanjing China
Abstract
AbstractRecently, physical tools for remotely stimulating mechanical force‐sensitive and temperature‐sensitive proteins to regulate intracellular pathways have opened up novel and exciting avenues for basic research and clinical applications. Among the numerous modes of physical stimulation, magnetic stimulation is significantly attractive for biological applications due to the advantages of depth penetration and spatial‐temporally controlled transduction. Herein, the physicochemical parameters (e.g., shape, size, composition) that influence the magnetic properties of magnetic nanosystems as well as the characteristics of transient receptor potential vanilloid‐1 (TRPV1) and transient receptor potential vanilloid‐4 (TRPV4) channels are systematically summarized, which offer opportunities for magnetic manipulation of cell fate in a precise and effective manner. In addition, representative regulatory applications involving magnetic nanosystem‐based TRPV1 and TRPV4 channel activation are highlighted, both at the cellular level and in animal models. Furthermore, perspectives on the further development of this magnetic stimulation mode are commented on, with emphasis on scientific limitations and possible directions for exploitation.This article is categorized under:
Diagnostic Tools > Biosensing
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Funder
Youth Innovation Promotion Association of the Chinese Academy of Sciences
National Natural Science Foundation of China