Genetically Predicted Sleep Traits and Sensorineural Hearing Loss: A Mendelian Randomization Study

Author:

Gao Yan123,Qiu Yuanzheng1234,Lu Shanhong1234ORCID

Affiliation:

1. Department of Otolaryngology‐Head and Neck Surgery, Xiangya Hospital Central South University Changsha Hunan People's Republic of China

2. Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha Hunan People's Republic of China

3. Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province Changsha Hunan People's Republic of China

4. National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) Changsha Hunan People's Republic of China

Abstract

ObjectiveObservational studies suggest a potential association between sleep characteristics, sensorineural hearing loss (SNHL), and sudden SNHL (SSNHL), but causal evidence is scarce. We sought to clarify this issue using two‐sample Mendelian randomization analysis.MethodsThe inverse‐variance weighted (IVW) method was performed as primary analysis to assess bidirectional causal associations between sleep traits (chronotype, sleep duration, insomnia, daytime sleepiness, and snoring) and SNHL/SSNHL using publicly available Genome‐Wide Association Studies summary data from two large consortia (UK Biobank and FinnGen). Sensitivity analyses, including Mendelian randomization (MR)‐Egger, Mendelian randomization pleiotropy residual sum and outlier, weight median, Cochran's Q test, leave‐one‐out analysis, and potential pleiotropy analysis, were conducted to ensure robustness.ResultsIVW analysis found suggestive associations of morning chronotype (odds ratio [OR] = 1.08, 95% confidence interval [CI] = 1.01–1.16, p = 0.031) and daytime sleepiness (OR = 1.88, 95% CI = 1.24–2.87, p = 0.003) with SNHL onset. Additionally, morning chronotype was nominally associated with SSNHL onset using IVW method (OR = 1.37, 95% CI = 1.10–1.71, p = 0.006). However, there was no evidence for the causal effect of SNHL and SSNHL on different sleep traits (all p > 0.05). Sensitivity analysis showed that the results were stable.ConclusionWithin the MR limitations, morning chronotype and daytime sleepiness were underlying causal contributors to the burden of SNHL, indicating that optimal sleep might facilitate the prevention and development of SNHL.Level of Evidence3 Laryngoscope, 2024

Funder

Natural Science Foundation of Hunan Province

National Natural Science Foundation of China

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3