Polycaprolactone and its derivatives for drug delivery

Author:

Pawar Ranjitsinh1,Pathan Anam2,Nagaraj Srishti3ORCID,Kapare Harshad2,Giram Prabhanjan24ORCID,Wavhale Ravindra2ORCID

Affiliation:

1. Department of Pharmaceutics, Poona College of Pharmacy Bharati Vidyapeeth (Deemed to be University) Pune Maharashtra India

2. Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research Pune Maharashtra India

3. School of Pharmaceutical Sciences University of Copenhagen København Denmark

4. Department of Pharmaceutical Sciences The State University of New York Buffalo New York USA

Abstract

AbstractPolycaprolactone (PCL) is polymer of 21st centuries. PCL is a biodegradable and biocompatible polymer used for various healthcare applications. This review explores the properties, synthesis, and processing of PCL. The use of PCL polymer for nanoparticles (NPs), microparticles, films, and fibers offers several advantages for biomedical applications. The review highlights the potential of PCL‐based materials for tissue engineering, drug delivery, wound healing, and implantable medical devices. We also critically analyzed challenges in PCL‐based materials and the strategies used to overcome for successful translation into clinical applications. Overall, this review provides a comprehensive overview of PCL as a valuable biomaterial for healthcare applications.

Publisher

Wiley

Subject

Polymers and Plastics

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