Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging

Author:

Xie Chen12ORCID,Wu Yue1ORCID,Chau Ho‐Fai1ORCID,Zhang Tao3,Wong Carlos Tinlong4,Yeung Yik‐Hoi1ORCID,Lam Pak‐Lun1ORCID,Bünzli Jean‐Claude G.5ORCID,Charbonnière Loïc J.2ORCID,Law Ga‐Lai4ORCID,Wong Ka‐Leung1ORCID

Affiliation:

1. Department of Chemistry Hong Kong Baptist University 224 Waterloo Rd, Kowloon Tong Kowloon Hong Kong SAR P. R. China

2. Equipe de synthèse pour l'analyse (SynPA) Institut Pluridisciplinaire Hubert Curien (IPHC) Département des sciences analytiques (DSA) ‐ UMR 7178 CNRS/Université de Strasbourg ECPM Bâtiment R1N0, 25, rue Becquerel 67087 Strasbourg Cedex 2 France

3. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science Guangdong Provincial Key Laboratory of Laser Life Science, and College of Biophotonics South China Normal University Guangzhou 510631 P. R. China

4. Department of Applied Biology and Chemical Technology State Key Laboratory of Chemical Biology and Drug Discovery The Hong Kong Polytechnic University Hong Kong P. R. China

5. Institut des Sciences et Ingénierie Chimiques École Polytechnique Fédérale de Lausanne (EPFL) 1015 Lausanne Switzerland

Abstract

AbstractBioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real‐time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)‐based complex is reported as a small‐molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights.

Publisher

Wiley

Subject

Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Emerging frontiers in rare-earth element chemical biology;Coordination Chemistry Reviews;2024-11

2. Rare Earths—The Answer to Everything;Molecules;2024-02-01

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