Association of joint hypermobility with range of cervical motion and its impact on the motor unit loss in patients with Hirayama disease

Abstract

AbstractIntroduction/AimsSome patients with Hirayama disease (HD) may have generalized joint hypermobility (GJH), which may excessively increase cervical range of motion (ROM) and then worsen the HD. The purpose of this study was to identify the frequency of GJH in HD patients and to analyze the effect of GJH on cervical ROM and the severity of HD.MethodsThe Beighton scoring system (≥4) was used to diagnose GJH in 84 HD patients. All patients underwent assessments of cervical‐flexion/extension ROM; motor unit number estimation in bilateral abductor pollicis brevis (APB) muscles; handgrip strength; and the disabilities of the arm, shoulder, and hand assessments.ResultsConcomitant GJH was identified in 20 (23.8%) HD patients. The HD patients with GJH exhibited greater cervical‐flexion (P < .001) and cervical‐extension (P = .033) ROM than those without GJH. Both greater single motor unit potential amplitudes (symptomatic side: P = .005; less‐symptomatic side: P = .011) and lower motor unit numbers (symptomatic side: P = .008; less‐symptomatic side: P = .013) in bilateral APB, along with lower compound muscle action potential amplitudes on the symptomatic‐side APB (P = .039), were observed in patients with GJH than those without GJH. There was a mild negative correlation between motor unit number and cervical‐flexion ROM in HD patients (symptomatic side: r = −0.239, P = .028; less‐symptomatic side: r = −0.242, P = .027).DiscussionThe frequency of GJH in HD patients may be higher than in the general population. Importantly, GJH may exacerbate excessive cervical‐flexion ROM, thereby worsening motor unit loss in HD patients. A cautious approach should be taken when treating HD due to possible comorbid GJH.