Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts

Author:

Vázquez Ramiro1,Licandro Simonetta Andrea1,Astorgues-Xerri Lucile2,Lettera Emanuele1,Panini Nicolò1,Romano Michela1,Erba Eugenio1,Ubezio Paolo1,Bello Ezia1,Libener Roberta3,Orecchia Sara3,Grosso Federica3,Riveiro María Eugenia2,Cvitkovic Esteban24,Bekradda Mohamed2,D'Incalci Maurizio1,Frapolli Roberta1

Affiliation:

1. Laboratory of Cancer Pharmacology; IRCCS-Istituto di Ricerche Farmacologiche Mario Negri; Milan Italy

2. Oncology Therapeutic Development; Clichy France

3. Cytogenetic and Molecular Pathology Laboratory, Pathology Unit, Oncology; SS Antonio e Biagio e Cesare Arrigo General Hospital; Alessandria Italy

4. Oncoethix SA (now Oncoethix GmbH, a wholly owned subsidiary of Merck Sharp & Dohme Corp); Lucerne Switzerland

Funder

Fondazione Buzzi Unicem Onlus

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference33 articles.

1. Malignant mesothelioma;Ahmed;Pak J Med Sci,2013

2. Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group;Husain;Arch Pathol Lab Med,2009

3. Malignant pleural mesothelioma;Ceresoli;Ann Oncol,2006

4. Pleural mesothelioma: little evidence, still time to do trials;Treasure;Lancet,2004

5. Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma;Scherpereel;Eur Respir J,2010

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