Synthesis of 3 H, 13 C2 , 2 H4 14 C-SCH 430765 and 35 S-SCH 500946, potent and selective inhibitors of the NPY5 receptor

Author:

Hesk D.1ORCID,Koharski D.1,McNamara P.1,Royster P.1,Saluja S.1,Truong V.1,Voronin K.1

Affiliation:

1. Department of Process Research and Development; Merck Research Laboratories, Merck & Co., Inc.; Rahway NJ USA

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference12 articles.

1. A receptor subtype involved in neuropeptide-Y-induced food intake;Gerald;Nature,1996

2. Activation of the NPY Y5 receptor regulates both feeding and energy expenditure;Hwa;Am J Physiol,1999

3. Identification and characterization of pseudoirreversible nonpeptide antagonists of the neuropeptide Y Y5 receptor and development of a novel Y5-selective radioligand;Mullins;Eur J Pharmacol,2008

4. Greenlee W Huang Y Kelly J McCombie S Stamford A Wu Y PCT Int. App 2002

5. Greenlee W Huang Y Kelly J McCombie S Stamford A Wu Y PCT Int. App 2003

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