The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

Author:

Orlik Johanna1,Schüngel Sven1,Buitrago-Molina Laura Elisa1,Marhenke Silke1,Geffers Robert2,Endig Jessica1,Lobschat Katharina1,Rössler Stephanie3,Goeppert Benjamin3,Manns Michael P.1,Gross Atan4,Vogel Arndt1

Affiliation:

1. Department of Gastroenterology, Hepatology and Endocrinology; Hannover Medical School; Hannover Germany

2. Genome Analytics; Helmholtz Center for Infection Research; Braunschweig Germany

3. Institute of Pathology, University Hospital; Heidelberg Germany

4. Department of Biological Regulation; Weizmann Institute of Science; Rehovot Israel

Funder

German-Israeli Foundation

Deutsche Forschungsgemeinschaft (Rebirth II excellence cluster, KFO119 and TRR77

Publisher

Wiley

Subject

Hepatology

Reference39 articles.

1. Ferlay J Soerjomataram I Ervik M Dikshit R Eser S Mathers C 2013 http://globocan.iarc.fr

2. Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States;Altekruse;Am J Gastroenterol,2014

3. Hepatocellular carcinoma;El-Serag;N Engl J Med,2011

4. The Bcl-2 family: roles in cell survival and oncogenesis;Cory;Oncogene,2003

5. The hallmarks of cancer;Hanahan;Cell,2000

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