Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell

Author:

Hu Zhilan1,Guo Donglin1,Yip Shirley S.M.1,Zhan Dejin1,Misaghi Shahram1,Joly John C.1,Snedecor Bradley R.1,Shen Amy Y.1

Affiliation:

1. Dept. of Early Stage Cell Culture; Genentech Inc.; 1 DNA Way South San Francisco CA 94080

Publisher

Wiley

Subject

Biotechnology

Reference30 articles.

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2. Industrialization of mAb production technology: the bioprocessing industry at a crossroads;Kelley;mAbs.,2009

3. CHO cells in biotechnology for production of recombinant proteins: current state and further potential;Kim;Appl Micrbiol Biotechnol.,2012

4. Market Development of Biopharmaceuticals

5. Biopharmaceutical benchmarks;Walsh;Nat Biotechnol.,2010

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