Affiliation:
1. Department of Neurology Washington University in St. Louis St. Louis MO USA
2. Mallinckrodt Institute of Radiology Washington University in St. Louis St. Louis MO USA
3. Department of Neurology University of Texas Southwestern Medical Center Dallas TX USA
4. C2N Diagnostics St. Louis MO USA
Abstract
The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that Alzheimer disease pathology is uncommon in MS patients. In 100 MS patients, the rate of amyloid‐β plasma biomarker positivity was approximately half the rate in 300 non‐MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid‐β pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research. ANN NEUROL 2024;96:453–459
Funder
National Institute of Neurological Disorders and Stroke
National Institute on Aging
Alzheimer's Drug Discovery Foundation