Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics-Reference-Cited by-同舟云学术

Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics

Published:2016-06-20 Issue:8-9 Volume:35 Page:369-381
ISSN:1868-1743
Container-title:Molecular Informatics
language:en
Short-container-title:Mol. Inf.

Author:

D'Ursi Pasqualina¹,Guariento Sara²,Trombetti Gabriele¹,Orro Alessandro¹,Cichero Elena²,Milanesi Luciano¹,Fossa Paola²,Bruno Olga²

Affiliation:

1. Institute for Biomedical Technologies e National Research Council (ITB-CNR); Via Fratelli Cervi 93 20090 Segrate (MI Italy

2. Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences; University of Genoa; Viale Benedetto XV 3 16132 Genova (GE Italy

Funder

Alzheimer Association

Italian Ministry of Education and Research through the Flagship InterOmics

HIRMA

European MIMOmics

Publisher

Wiley

Subject

Organic Chemistry,Computer Science Applications,Drug Discovery,Molecular Medicine,Structural Biology

Reference52 articles.

1. Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use

2. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

3. cAMP-Specific Phosphodiesterase-4 Enzymes in the Cardiovascular System

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