USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells

Author:

Lin Ruirong123,Nie Jia2,Ren Jiazi23,Liang Rui23,Li Dan23,Wang Ping4,Gao Chengjiang5,Zhuo Changhua1,Yang Chunkang1,Li Bin23

Affiliation:

1. Department of Gastrointestinal Surgical Oncology; Fujian Provincial Key Laboratory of Tumor Biotherapy; Fujian Cancer Hospital & Fujian Medical University Cancer Hospital; Fuzhou China

2. Shanghai Institute of Immunology; Shanghai JiaoTong University School of Medicine; China

3. Key Laboratory of Molecular Virology & Immunology; CAS Center for Excellence in Molecular Cell Science; Unit of Molecular Immunology; Institut Pasteur of Shanghai; Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences Medical School; Shanghai China

4. Department of Central Laboratory; School of Life Science and Technology; Shanghai Tenth People's Hospital of Tongji University; Tongji University; Shanghai China

5. Department of Immunology and Key Laboratory of Infection and Immunity of Shandong Province; Shandong University School of Basic Medical Sciences; Jinan China

Funder

National Basic Research Program of China Grants

National Natural Science Foundation of China

SMCST

Shanghai Academic Research Leader

National Clinical Key Specialty Construction Program of China

Shanghai ‘Rising Star’ program

CAS ‘100-talent’ program

Shanghai leading talent program and the National Science Foundation of Distinguished Young Scholars

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

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