Drivers of de novo Serine/Glycine synthesis in acute leukemia
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Published:2023-08
Issue:17
Volume:597
Page:2145-2146
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ISSN:0014-5793
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Container-title:FEBS Letters
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language:en
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Short-container-title:FEBS Letters
Author:
Verstraete Paulien12,
De Keersmaecker Kim12,
Kampen Kim Rosalie123ORCID
Affiliation:
1. Laboratory for Disease Mechanisms in Cancer, Department of Oncology KU Leuven Leuven Belgium
2. Leuven Cancer Institute (LKI) Leuven Belgium
3. Department of Radiation Oncology (MAASTRO) GROW School for Oncology and Reproduction Maastricht The Netherlands
Abstract
Cancer cells hijack metabolic pathways in order to provide themselves with building blocks to support their proliferation and survival. Upregulation and addiction to de novo serine/glycine synthesis is an example of metabolic rewiring in cancer cells whereby serine and glycine are synthesised via a side branch of glycolysis. In this review, we focus on upregulation of endogenous serine/glycine production in acute leukemia, namely T‐cell acute leukemia (T‐ALL) and acute myeloid leukemia (AML). Several genetic lesions directly driving the serine/glycine addiction in acute leukemia have been established. Additionally, indirect regulation of de novo serine/glycine synthesis is observed in acute leukemia.
Funder
Federation of European Biochemical Societies
Fonds Wetenschappelijk Onderzoek
Koninklijke Nederlandse Akademie van Wetenschappen
KU Leuven
KWF Kankerbestrijding
Stichting Tegen Kanker
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics