A γ‐glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells

Author:

Wang Shuxuan1,Chen Yao1,Fang Houshun1,Xu Yan1,Ding Ming1,Ma Chunshuang1,Lin Yanyan1,Cui Zhiyan1,Sun Huiying1,Niu Qun2,Sun Shuzhang2,Zhou Bin‐Bing S.134,Xiao Ning2ORCID,Li Hui134

Affiliation:

1. Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Pediatric Translational Medicine Institute Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University China

2. Clinical Research Center Longhua Hospital Shanghai University of Traditional Chinese Medicine China

3. Fujian Children's Hospital Fujian Branch of Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine China

4. Department of Pharmacology and Chemical Biology School of Basic Medicine and Collaborative Innovation Center for Translational Medicine School of Medicine Shanghai Jiao Tong University China

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Reference31 articles.

1. Resistance to antifolates

2. Roles of folylpoly‐gamma‐glutamate synthetase in therapeutics with tetrahydrofolate antimetabolites: an overview;Moran RG;Semin Oncol,1999

3. Glutamyl hydrolasepharmacological role and enzymatic characterization

4. Secretion of gamma‐glutamyl hydrolase in vitro;O'Connor BM;Cancer Res,1991

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