Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194-Reference-Cited by-同舟云学术

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Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194

Published:2020-08-30 Issue:19 Volume:594 Page:3156-3169
ISSN:0014-5793
Container-title:FEBS Letters
language:en
Short-container-title:FEBS Lett.

Author:

Kamble Pradnya R.¹,Rane Sanjana¹,Breed Ananya A.¹,Joseph Shaini²,Mahale Smita D.¹,Pathak Bhakti R.¹^ORCID

Affiliation:

1. Division of Structural Biology ICMR‐National Institute for Research in Reproductive Health Mumbai India

2. Genetic Research Center ICMR‐National Institute for Research in Reproductive Health Mumbai India

Funder

Indian Council of Medical Research

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/1873-3468.13899

Reference40 articles.

1. Biochemical Characterization of Trop-2, a Cell Surface Molecule Expressed by Human Carcinomas: Formal Proof that the Monoclonal Antibodies T16 and MOv-16 Recognize Trop-2

2. Human trophoblast cell-surface antigens defined by monoclonal antibodies.

3. Expression of Trop2 Cell Surface Glycoprotein in Normal and Tumor Tissues

4. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

5. Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications

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1. A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy;Acta Pharmaceutica Sinica B;2024-08

2. Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy;Proceedings of the National Academy of Sciences;2023-11-14

3. Targeting Trop-2 as a Cancer Driver;Journal of Clinical Oncology;2023-10-10

4. Comparison of Anti-Trop2 Extracellular Domain Antibodies Generated Against Peptide and Protein Immunogens for Targeting Trop2-Positive Tumour Cells;Applied Biochemistry and Biotechnology;2023-09-01

5. Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/β-catenin positive feedback loop;Journal of Advanced Research;2023-06

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