The magnified view: from ancient trinkets to single nuclear pore complexes
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Published:2023-10
Issue:20
Volume:597
Page:2590-2596
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ISSN:0014-5793
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Container-title:FEBS Letters
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language:en
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Short-container-title:FEBS Letters
Author:
Fichtman Boris1,
Harel Amnon1ORCID
Affiliation:
1. Azrieli Faculty of Medicine Bar‐Ilan University Safed Israel
Abstract
A journey from the earliest known use of lenses and magnifying glasses in ancient times, through the development of microscopes and towards modern electron microscopy techniques. The evolving technology and improved microscopes enabled the discovery of intracellular organelles, the nucleus and nuclear pore complexes (NPCs). Current advances have led to composite three‐dimensional models showing NPC structure in unprecedented detail but relying on the averaging of many images. A complementary approach is field emission scanning electron microscopy providing topographic surface images that are easily and intuitively interpreted by our brain. Recent advances in this technique have made it possible to expose nuclei from human cells and to focus on individual NPCs and their architectural features.
Funder
Israel Science Foundation
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics
Cited by
1 articles.
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